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When the Central Intelligence Agency or the State Department, let alone the United Nations, was mentioned in conversation with a foreign-policy conservative, the reference would usually draw a derisive chuckle or a rolling of the eyes: those organizations had been captured by the appeasers, and could be counted on to respond insufficiently to threats.
Furthermore, it is not clear why about 30% of patients respond insufficiently to anti-TNF treatment [ 1].
A proportion of patients do not respond, insufficiently respond or lose an initial good response to classic TNF inhibitors.
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Low-dose MTX (≤15 mg/w) or MTX + LEF therapy was prescribed for patients responding insufficiently to the original DMARD s) therapy, intolerant to other DMARDs, in moderate to high disease activity or with prognostically unfavourable factors.
The eligible patients who had responded insufficiently to treatment with at least one disease-modifying antirheumatic drug (DMARD) or immunosuppressant were recommended for treatment with tocilizumab or TNF-α inhibitors by their attending physicians.
In patients responding insufficiently to MTX and/or other csDMARD strategies, with or without glucocorticoids, bDMARDs (TNF inhibitors, abatacept or tocilizumab, and, under certain circumstances, rituximab) should be commenced with MTX.
Biological agents have proven to be effective in patients responding insufficiently to MTX in randomised controlled trials (RCTs), not only in reducing disease activity and improving functional status, but in slowing radiological progression [ 9- 15].
Mr. Kamau, the transportation secretary, dismissed criticism that firefighters were slow to respond or insufficiently equipped to fight the blaze, which started in the immigration area in the central building.
Meta-analytical findings have indicated that a substantial number of patients do not or insufficiently respond to self-management interventions [ 25, 34].
Changing the neoadjuvant chemotherapy regimen in insufficiently responding breast cancer is not a standard policy.
To select patients insufficiently responding to prior therapy, a two-step selection process was used.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com