Transcription factor genes responding to these signals, concomitantly with their target genes, then have a capacity to specifically amplify the expression of these target genes.
Specific mutations in the FERM domain inhibit cytokine receptor association and concomitantly abrogate Jaks' ability to respond to ligand binding.
These data indicate that astrocytes in the IBZ respond to MSC treatment and increase tPA and concomitantly decrease PAI-1 gene expression.
Concomitantly, the activation of two other genes that commonly respond to environmental stress, chitinase and pectin methylesterase 1, were detected.
When expression of PTEN and mutations of KRAS, BRAF and PIK3CA are concomitantly ascertained, up to 70% of mCRC patients unlikely to respond to anti-EGFR therapies can be identified.
U2OS-HRE cells responded to hypoxia (1% oxygen) by stabilization of HIF1A protein and concomitantly displayed an approximately 10-fold induction of luciferase activity.
One explanation proffered was that expression of a functional p53 restores the ability to recognise, repair and respond to treatment-induced DNA damage and effectively attenuates or neutralises the effects of concomitantly administered drugs (Zeimet and Marth, 2003).
The fact that a dense cytoplasm with starch-containing organelles was observed concomitantly with nanoparticle aggregates in the cytosol, suggests that plant cells could respond to the presence of a high density of nanoparticles by changing their subcellular organization.
Concomitantly, antioxidant compounds (such as ascorbic acid), total polyphenols and ureides responded to salinity in a genotype-dependent manner; either they increased, decreased or were unaffected.
Moreover, patients treated concomitantly with MTX have a lower risk of developing such antibodies, similarly to those responding to therapy [78].
