Sentence examples for respiratory safety from inspiring English sources

Current practice in respiratory safety pharmacology generally follows the guidance provided by the ICH document S7A and, in general, focuses on measures of pulmonary ventilation.

To evaluate drug-induced effects on respiratory function, respiratory safety pharmacology studies generally emphasize the use of conscious animal models and measures of pulmonary ventilation.

This study was designed to provide a comprehensive nonclinical respiratory safety pharmacology assessment using respiratory inductance plethysmography (RIP) concomitant with a standard cardiovascular (CV) safety assessment in non-human primates (NHP) in a single cardiorespiratory study.

The objective of this review is to discuss the value and utility of the methods and measurement endpoints currently available for assessing respiratory function to help optimize the design of respiratory safety pharmacology studies.

Thus, a variety of methodologies and measurement endpoints are available for detecting and characterizing drug-induced respiratory dysfunction in animal models and should be considered when designing respiratory safety pharmacology studies.

The aim of the present work was to improve the strategy for respiratory safety testing by a) evaluating a telemetered pleural pressure – HOP (PP-HOP) model and b) evaluating a crossover study design protocol in the WBP model to reduce variability and animal usage.

A tailored healthy homes improvement package significantly improves self-reported respiratory health and safety, reduces respiratory health and injury hazards, and can be implemented in concert with a mobile clinical setting.

The backup safety respiratory frequency of the ventilator was set at 6 by minute to allow expiratory maneuvers of 10 s.

Subacute toxicity, immunotoxicity, and respiratory, cardiovascular, and CNS safety pharmacology were analyzed in rodents and non-rodents, and genotoxicity was assessed in human peripheral blood.

Prior to his role as CMO, Paul was Vice President & General Manager of 3M's Personal Safety Division, a global leader in solutions for worker health and safety, including respiratory protection, hearing conservation, eye and face protection, and fall protection.

Flow rates may be titrated to the evolving status of respiratory distress, but the safety of this practice is uncertain because subsequent changes in generated pressure are not measured.