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Asthma is another example of a type I reaction, but, whereas asthma is localized to the respiratory region of the body, anaphylaxis has effects throughout the organism.
As a result, it is important to study the effects of gas exposure to the lower respiratory region.
This is accomplished by mucociliary transport in conducting airways and to a large extent by alveolar macrophages in the respiratory region.
However, there are few well-controlled studies that have examined the upper respiratory region, which result in interpretive problems for toxicologic pathologists.
Hence, innervation of the olfactory region and the respiratory region is only provided by the ophthalmic nerve and the maxillary nerve, respectively.
These studies suggest that a low Km pathway for NNK activation is also present in the nose and that this pathway is localized predominantly in the respiratory region.
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The terminology of respiratory regions within the caudal pons is confusing even for many of us in the field.
In our experiments we include the entire hindbrain and the neurokinin 1 receptor is expressed in many places outside the respiratory regions we have focused on here.
Our next-generation sequencing (NGS) approach not only allows us to identify the uptake transporter for SR01 that explains the region-specific differences of SR101-labeling observed in the cardio-respiratory regions of the brainstem (Schnell et al. 2012), but also sheds some light on a more general heterogeneity of astrocytes.
We also tested potential confounding by respiratory infections, region of study, sex, cumulative daily use of as-needed β-agonist inhalers, and weekend.
One desirable route of nanomedicine delivery is through inhalation; a high percentage of inhaled nanomaterials preferentially deposit in the respiratory, alveolar region, the epithelial layer of which covers approximately 150 m and thus represents a large surface area for nanoparticle uptake and potential translocation to the pulmonary interstitium and cardiovasculature.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com