Exact(8)
In the single- and repeated-dose groups, 44 and 37, respectively, completed the entire study.
Discontinuation of treatment, mainly due to adverse events, was frequent (13% in the standard dose group vs. 24% in the high dose group), and only 66%and50%0%, respectively, completed 14 days of randomised treatment.
Nine volunteers (Mean ± SD for age, height, body mass, and body mass index = 26.7 ± 3.1 yrs, 176 ± 6.5 cm, 77.8 ± 10.9 kg, and 25.2 ± 3.1 kg/m2, respectively) completed a cuff ischemia and stepwise incremental exercise test in session one, followed by the Win45 and Win60 tests (load factor = 75 g/kg body weight) in random order in subsequent sessions.
Of 20 intervention and 13 control subjects, 19 (95%) and 10 (77%), respectively, completed follow-up.
Of these, 590 (74.87%) and 339 (76.18%), respectively, completed the questionnaires 6 months after the intervention.
Before and after the course, 20 (10.9%) and 37 (20.2%) participants, respectively, completed a faultless test.
Sixty-five Sixty-five and sixtyrespatientsy, completed 12 weeks of therespectively
Fifty healthy females and males (comprising 70% and 30% of the cohort, respectively) completed the study.
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