Testing its inherent biodegradability and its potential bioaccumulation will exclude or confirm the respective vPvB characteristics; otherwise it will be advisable to substitute this substance.
The value of r has similarly been normalized r = (rp−br)/rmax where rp is the measured fluorescence intensity of the rebinding species, br the background signal, and rmax the fluorescence intensity when only the 'rebinding' species (e.g. CaM-A647 in complete absence of CaM-A488) is bound to the respective peptide under otherwise identical experimental conditions to the rebinding step.
Statistical significance was evaluated by unpaired Student's t-test (or by Anova-2way test for line graphs), with reference to respective controls (unless otherwise indicated) and expressed as p values within figures or in figure legends.
One control subject was transiently positive for a single autoantibody before the end point in the respective case subject; otherwise no control subjects developed positive autoantibodies (even after their case subject reached the end point).
The category was evaluated as 1 if the value of a variable dropped within a subset given by the respective cut point otherwise it was evaluated as 0. The settings of cut points were based on the specification and behavior of an impurity function [ 22].
The impacts were assumed to be linear with the respective penetration rates, unless otherwise indicated.
Both variables, t2009 and t2012, take the value 1 for the respective years, but zero otherwise.
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Accordingly, countries across the world had begun to relax the clause to restrict monopolies in order to protect private corporations of their respective countries, as it otherwise threatened business and employment of key stakeholders in their respective countries.
