They were compared with the respective matrix communities and their contribution to local species richness was evaluated.
In order to obtain solid lipid nanoparticle dispersions that meet the requirements for an acceptable pharmaceutical product, the manufacture of reproducible product qualities preferably containing the stable crystal form of the respective matrix lipid is necessary.
To calculate the underlying sample sizes of the correlation matrices, we used the conservative harmonic mean of the sample sizes of the respective matrix (e.g. Stajkovic et al. 2009; Viswesvaran and Ones 1995), leading to N = 1159 in the external model and N = 3363 in the internal model.
This value was then multiplied with the dilution factor of 8 and corrected for the recovery of the extraction step of the respective matrix.
For the determination of specific analytes at a very high level of sensitivity, more dedicated methods (validated for the respective matrix) are recommended.
In case of r a and r b are measured, the respective matrix can be inverted in (nearly) all cases since it is of the form (12) ∈; = ∗ 0 0 ∗.
The TRANSFAC identifier of the respective matrix, the number of hits in the 96 induced gene promoters, the number of hits in the 100 non-regulated control gene promoters, and the corresponding fold occurrences are given in this table.
For the calculation of the average values, all contaminated samples were taken into considerations; for values below the LLOQ, half of the LLOQ of the respective matrix was used.
The TRANSFAC identifier of the respective matrix, the number of hits in the 110 different sequences (205 bp) of induced gene promoters, the number of hits in the 110 different sequences (205 bp) of control (non-regulated) gene promoters, and the corresponding fold occurrences are given in this table.
However, depending on the properties of the nanoparticle suspensions, the respective matrix, and the parameters of the procedure (e.g., ENP concentration, pH, salinity), the recoveries determined in different studies ranged, mostly, from ∼65%% up to ∼110%% of the initial ENP concentration [ 31, 40, 51].
