In order to account for potential confounding between genotype variants, the main effect terms for maternal and infant TF and HFE variant status, along with their respective interaction with MBL, were modeled together.
Starting from a constant null model with block and species identity as random terms, the fixed effects were added stepwise in the following sequence: fertilization, shade, fertilization × shade interaction, functional group identity (grass vs. forb) and growth stature (tall vs. small) and their respective interaction with fertilization and shade.
Although the effects of birth season and birth year were statistically non-significant (P > 0.05), their respective interactions with sex and farm/owner were statistically significant (P < 0.01), what translated into an increase of 40.5% in the specificity and of 0.6% of the sensibility of the model designed, when such interactions were included.
For litterbags employed at urban and periurban sites, differences in mass loss between species, origin of leaf litter, and decomposition site were analyzed with Kruskal-Wallis tests, and the respective interactions with a three-way ANOVA, despite mass loss values being measured in percent.
However, our data do not rule out a possibility that colocalization of ClpX and FtsZ could also be due to their respective interactions with other proteins.
Jedrychowski et al. reported that early weaning is associated with slower cognitive development, but they did not include significant confounders such as exposure to mercury, lead, fish, and their respective interactions with neurodevelopment.
Nonetheless, these discordances underlie the complexity of in vivo role ATG5 or autophagy partakes in post-ligated SMGs and hint at their respective interactions with other stress-triggered signaling pathways.
None of the other risk factors analysed (gender, education, geographic location, body mass index (BMI), stroke, cardiovascular disease, smoking), nor their respective interactions with the age risk factor, were statistically significant (p>0.05 for all).
A list of the 11 identified nuclear proteins and their respective interaction index with lamin A or progerin is shown in Figure 3 figure supplement 1C.
Interactions of hs-CRP and metabolic syndrome with cognitive functioning were tested by including the respective interaction term in the multivariate linear regression models.
Although no interactions were detected for nsp11, which was predicted to be small polypeptide with 13 amino acids, fusion of nsp11 with nsp10 strengthened the respective interactions of nsp10 with nsp14 and nsp16.
