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There were 59,798 ever-users and 422,235 never-users of human insulin, with respective numbers of incident breast cancer of 559 (0.93 %) and 4,711 (1.12 %), and respective incidence of 207.9 and 215.1 per 100,000 person-years.
The respective incidence of these two phenomena has not been previously studied in humans.
Each line describes an augmented atom as SMARTS string and its respective incidence, tab-separated.
The full list of augmented atoms used in this then and now comparison with their respective incidence is provided as supporting information in Additional file 2. Analysis of PubChem chemical substance descriptions (PubChem Substance: 104,669,789 records) and the unique set of chemical structures after PubChem normalization processing (PubChem Compound: 46,704,121 records) was performed.
The full list of atom types with their respective incidence is provided for Substance and Compound as supporting information in Additional file 3. The total number of atom environments with radius r = 1 is 299,609 for Substance [100,411 (33.5%) singletons] and 109,306 for Compound [31,163 (28.5%) singletons], a 38× and 69×, respective, fold increase over r = 0.
The full list of atom environments with radius r = 3 with their respective incidence is provided for Substance and Compound as supporting information in Additional file 4. The sets of atom environments with radii r = 1, r = 2 and r = 3 partly overlap, as illustrated in the Venn diagrams shown in Fig. 25.
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We plotted the respective incidences in Figure 4.
With regard to the latter, the diagnosis-based prevalence remained high whereas a decrease of the respective incidences was seen.
For patients with stage 3 disease (estimated GFR 30-59 mL/min/1.73 m), the respective incidences were 24.3% and 1.3%.
The relative risks of developing litigation later on in each category of patients were computed by comparing the respective incidences.
The incidences of induced laryngeal and tracheal tumors were very low, and in no case were these tumors statistically significantly different from the respective incidences in controls.
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