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As explained above, it should depend on the respective fitness of the variants in different tissues and on tissue specificity.
Thereby the clonal sequence representation is expected to be directly proportional to the respective fitness of the variant in vivo.
Using classical Wright-Fisher population genetics formalism, networks contributed to the next generation of networks according to their respective fitness.
Also, through understanding reversibility on the levels of both phenotype and genotype, one could catch a glimpse at the structure of the respective fitness (or adaptive) landscape.
Clearly, if hosts and parasites use the same resource base for reproduction there must be a trade-off between their respective fitness.
The relationship between HRR% and activity accounts were plotted for all subjects and regression lines were generated for each respective fitness group.
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Any process in which competing solutions replicate with errors and numbers of their copies depend on their respective fitnesses is the evolutionary optimization process.
We define the respective fitnesses of the three possible genotypes, assuming a genic selection model, which has been shown to be a good approximation for systems under weak selection (Garcia-Dorado and Caballero 2000).
Going beyond most previous studies we have also corrected the home/away-asymmetry [7], [8], i.e. the match results are projected on the fictive results in a neutral stadium, in order to extract the respective team fitness without the home/away-bias.
Each generation is generated by multinomial sampling, where the probability of choosing an allele of a given type (ancestral or derived) is weighted by its respective (marginal) fitness.
The kinship theory is a kin selection model, where matrigenic and patrigenic alleles experience different patterns of relatedness in the social environment (for example, individuals tend to encounter more matrilineal than patrilineal relatives), and as a result, their expression has different consequences for their respective inclusive fitnesses (Haig, 2002, pp 5 6; Figure 1).
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