The increased expression of delta-1-pyrroline-5-carboxylate dehydrogenase transcripts may indicate a redistribution of nutritional resources in cap tissue as suggested by Wagemaker et al. (26).
Although this may beneficially enhance the incretin effect, GIP is thought to promote storage of energy resources in peripheral tissues, possibly due to direct effects on adipocytes [ 34, 35].
However, many of these resources, although broad in tissue coverage, are limited in the number of samples analyzed for each tissue type (eg, Symatlas).
The CPCTR differs from most other tissue resources in that (1) all accrued cases have undergone standardized pathology review, (2) the clinical data have been carefully collected using a standardized quality-controlled method, and (3) cases have been accrued across five states, from four academic centers, and from more than 15 hospitals.
Using computational methods to integrate other genomic resources in order to predict tissue-specific transcription factor binding is therefore an important research challenge.
In monogamous species, males display a lower investment in sexual tissues and a higher commitment of resources to tissues involved in female transport, protection, and feeding assistance.
Nitrogen availability exerts strong control of plant biomass partitioning and this response has been interpreted as plants maximising resource capture through allocating resources to the tissue in which the limiting resource is acquired [3].
EST databases of head kidney tissue are likely to become important resources in which immune-related genes can be identified.
The rhythmic variations in resources influence stable isotope ratios in tissues resulting in the circannual variability found in hair and teeth reported here.
Here, we present an integrated data resource combining tissue expression with phenotypes in mouse lines and bringing us one step closer to consequence chains from a molecular level to a resulting phenotype.
