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Although a shortened version has been published previously (Independent UK Panel on Breast Cancer Screening, 2012), the Editorial Board felt that this is such an important issue in terms of resources, controversy and cost-benefit analysis, as well as potential patient benefit, that the whole report should be published in full here.
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To emphasize that protecting human research participants is not only of historical interest, there are resources on current controversies at Fear and Loathing in Bioethics (http://loathingbioethics.blogspot.com).blogspot.com
Because blog publishing technology makes it so easy to integrate other Internet materials directly into blog posts, bloggers draw one another, their audiences, and the creators of other Internet resources into dialog and controversy.
This article describes the development of the website Human Intelligence: Historical Influences, Current Controversies, Teaching Resources (http://www.intelltheory.com/).com/
Besides statistical uncertainty (sampling variation) with regard to costs and effects, every economic evaluation may contain some degree of data imprecision (e.g. resource costs/prices) and methodological controversy (e.g. derivation of utility weights, discount rate), which should be accounted for.
In contrast, outcome measures, such as standardized mortality ratios, require far greater resources and are fraught with controversy.
Finally, pursuing this technology is not without controversy in terms of resource allocation and ethics [ 67].
"Climate change" and "over-exploitation of resources" are common subjects everywhere, not without controversy or resolution, but at least in public view.
In such cases, uncertainty and controversy are likely to influence resource allocation decisions.
All these issues are not merely bilateral and have strong probabilities to generate protracted regional disputes and controversies over the shared water resources.
Such interventions, though widely used, have generated controversy because of their significant resource implications and the lack of robust evidence with regard to their effectiveness at reducing transmission.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com