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Today, the data accumulation rate is hundreds of times higher than that when the Human Genome Project was first stated (NCBI Resource Coordinators, 2013).
The available genomic data have been extended for various species, from the initial goal of human and key lab model species to primates and domesticated animals and plants, and presently to endangered organisms with special scientific or cultural values (NCBI Resource Coordinators, 2013; Grigoriev et al., 2013).
That is, founders, acting in the role of resource coordinators and agents for a new venture (Bhide, 2000; Kirzner, 1973) often bring their personal social networks to the firm as their most valuable asset to provide resources necessary for successful emergence (Aldrich, Rosen, and Woodward, 1987; Hite, 1999; Larson and Starr, 1993).
Sixteen samples of a colorectal cancer RNA-Seq study [SRP010181 (Warren et al., 2012)] and 20 samples of low-coverage WGS data of the HapMap Project (The International HapMap Consortium, 2005) used by Warren et al. and Kim et al. have been obtained from the NCBI Sequence Read Archive (NCBI Resource Coordinators, 2013).
A binary hit matrix C R × L was constructed for all reads r ∈ R mapping to at least one allele a ∈ L of the reference with C r, a = 1 if read r mapped to allele a ; otherwise, C r, a = 0. Columns of rare alleles whose four-digit subtypes were not reported in allelefrequencies.net (Gonzalez-Galarza et al., 2011) or dbMHC (NCBI Resource Coordinators, 2013) at all were removed from the matrix.
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