The initial analysis was based on phylogeny, inter-patient distribution of maximum and mean distances, and Poisson fitness, and was able to resolve multiplicity of HIV transmission in 20 of 25 (80%) cases.
To resolve the multiplicity of HIV-1 infection in these cases, the following methods were applied: distribution of individual gag and env distances, shape analysis of highlighter plots, recombination analysis, and estimation of time to MRCA.
In the ensuing years the war resolved itself into a multiplicity of minor engagements, which need not be followed in detail.
Each such multiplicity was resolved as described previously [ 18, 20].
The second reason is that resolving anti-infective molecular target protein IDs also comes up against the problem of orthologous redundancy due to the multiplicity of viral, as well as bacterial sub-types, strains and species.
These limitations of the data set do not affect the organizing principle of multiplicity and will be resolved as the measure is applied to whole genome data on tumors.
Previous theoretical suggestions have yet to be validated in practice, whereas permutation testing does not resolve a discrepancy between the genomewide multiplicity of the experiment and the subset of markers actually tested.
One trivial way to resolve the above discrepancy might argue that the multiplicity of miRNA targets and the simultaneous down-regulation of many proteins might have a cumulative effect, eventually exerting a significant impact on cell fate, even though individual proteins are repressed to a very modest extent.
They resolve the problem based on the assumption that, although the multiplicities of these erroneous k-mers are high, their multiplicities should be lower than the nearby correct k-mers.
Such a multiplicity of stakeholders means that some issues can only be resolved at the highest level, with agreement on policy at an international level after significant stakeholder input.
