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The diastereomeric complexes were formed by adding the resolving agent to the racemic diol in a 0.5 1 molar ratio.
6-Methoxy-2-naphthylglycolic acid (6-MNGA) was designed as a novel acidic resolving agent, on the model of 2-naphthylglycolic acid (2-NGA).
During the preliminary evaluation of divergent synthetic products, it was discovered that 3a- fluoren-9-ylidenemethyl -2,3,4,5,3a-pentahydrocyclopenta[1,2-b]furan, was a remarkably improved chiral resolving agent for secondary alcohols.
A novel resolving agent, isopropylidene glycerol 3-carboxy-2-naphthoate 2, was designed on the basis of the consideration that replacement of phenyl group with a naphthyl group would improve the resolving ability of isopropylidene glycerol hydrogen phthalate 1 while also conferring more suitable physicochemical properties for such a specific use.
It is also used as a universal acidic chiral resolving agent for the resolution of racemic alcohols and amines [ 9].
A screening of crystallization conditions for the diastereomeric salts formed by L/D-malic acid and a common resolving agent, L-Ephedrine, in water is reported.
Similar(45)
Twelve homo-dipeptides derived from phenylglycine, Phg, and Cα-methyl phenylglycine, (αMe)Phg, were synthesized and tested as resolving agents in resolutions through selective crystallization of inclusion compounds.
This furan derivative is used as a divergent intermediate in the synthesis of our originally designed chiral resolving agents having various substitutions.
This paper presents an experimental and modelling approach to understanding the key conditions for diastereomeric resolutions of chiral amines by diacid resolving agents.
Whereas a wide array of similar dipeptides could be explored as resolving agents, it is expected to be difficult to rationally design potentially successful molecular structures.
When extended to multi-robotic scenarios where all robots possess more than one hypothesis of their position, there is an opportunity to do better by using robots, apart from obstacles, as 'hypotheses resolving agents'.
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