One hundred and forty HCV genotype-3a infected individuals including 16 acutely infected, 108 chronically infected and 16 with spontaneously resolved infection were recruited (John Radcliffe Hospital Oxford, MGH Boston, and the BBAASH cohort, Baltimore 31).
Other investigators reported an early emergence of HVR1-specific antibodies in a cohort of subjects infected during haemodialysis who resolved infection (Allander et al., 1997).
It now seems well established that the differences in adaptive immunity that characterizes chronically-infected patients and those with resolved infection are heavily influenced by immunological events during the initial phase of HBV replication.
This conclusion was supported by the finding that pulmonary γδ T cells, but not αβ T cells, isolated from mice that had resolved infection exhibited lung-homing capacity in both naive and infected recipients.
All 11 children infected with HBV and 12 of 16 children with the resolved infection were born to HBeAg positive mothers.
Of the children born to HBsAg positive mothers, 113.7.7%) were HBsAg positive, demonstrating the HBV infection, and 16 (5.4%) were HBsAg negative but anti-HBc positive, indicating past resolved infection, whereas none of the children born to HBsAg negative mothers was infected with HBV and only 0.9% had the resolved infection.
Limited data is available on the risk of hepatitis B virus (HBV) reactivation in patients with resolved infection undergoing kidney transplantation.
We did not have multiple time-points from individuals that naturally resolved infection and hence we are observing viral evolution in the context of a failed immune response with or without interferon alpha treatment.
Its presence may indicate a current or past resolved infection [ 26].
Anti-HBc positive – current or past (resolved) infection; anti-HBc negative – no infection.
He was repeatedly anti-HCV positive and HCV RNA negative, indicating resolved infection.
