In addition to these high-resolution imaging tools, we also employ several biomechanical and biochemical methods – each measures a unique aspect of the tissue's bulk properties and can be correlated with the spatially resolved changes in imaging.
The φd and C t) measurements are based on spatially resolved changes in X-ray attenuation coefficients in sequentially acquired 3-D micro-CT datasets using two (calibration and relative) analytical approaches.
There is a paucity of data on long-term, spatially resolved changes in microbial diversity and biogeography in marine systems, and yet these organisms underpin fundamental ecological processes in the oceans affecting socio-economic values of the marine environment.
Moreover, optical imaging has the ability to resolve changes in both oxy- and deoxy-hemoglobin within the brain using multiple wavelengths of light, which can potentially lead to the ability to discriminate blood flow and oxygen metabolism changes [ 5].
Using a distribution analysis, ORP was effective at resolving changes in dissolved methane levels even when the concentration was as low as 0.30 mg/L.
On the other hand, several VSDs are capable to resolve changes in membrane potential with a linear variation in fluorescence [25] and in the sub-millisecond range [6], [27].
Furthermore, previous research has used OCT to spatially resolve changes in cortical tissue during electrical stimulation [ 14, 15] and by utilizing the high spatial and temporal resolution of OCT, it will be possible to map changes in intensity during seizure progression and propagation through the intact brain.
Therefore, this tool has sufficient sensitivity to resolve changes in action potential waveform that might be responsible for PHD or PHP.
The cartilage from the stifle joint of the horse varies in thickness from 1,760 to 2,215 μm [ 51] and may provide an alternative source of cartilage for studies attempting to resolve changes in superficial and deep layers of equine cartilage.
Using a distinct methodology that is able to resolve changes in functional connectivity at high temporal resolution, we identified short-lived (100 200 ms) states that represent unique spatiotemporal patterns of neural activity.
This device measures changes in light attenuation at two wavelengths, 764 nm and 858 nm, and utilizes the modified Beer-Lambert law [ 38] with an age-dependent differential pathlength factor [ 39] to resolve changes in HbO2, HHb, and HbT concentrations within cortical brain tissue.
