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To test these hypotheses, we are elucidating the mechanism of AM1 function using an allelic series to define functional domains, proteomics to identify interacting proteins, and reverse genetics to resolve the functions of interacting proteins.
Thus, more extensive studies are needed to resolve the functions of the -141T/G polymorphism.
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Most of the research trying to resolve the function of p53 has been accomplished on transformed cells.
Furthermore, exogenous application of growth regulators is limited in its ability to resolve the function of endogenous ones.
The results of this study give us new insights into epigenetics of Campylobacteraceae and provide the groundwork to resolve the function of RM-systems in C. coli.
To resolve the function of ravines, it will be important to further explore their relationship with polycomb binding and other regulatory mechanisms.
If Arabidopsis is the only study material, we might not resolve the function of genes uniquely retained in the other rosids (e.g., V4 in Vitis, C17 in Carica, and P31 in Populus).
Ongoing svPINK1 over-expression studies should resolve the function of svPINK1, while we must also decide whether svPINK1 is a truly independent 'gene' transcribed from within the PINK1 genomic loci.
If we consider the underlying network where different biological functions are being described by groups of interacting genes, a single gene analysis does not resolve the biological functions that are affected primarily in disease conditions and are causal factors of the disease.
Systematic discovery and identification of mutant plants will help resolve the biological functions of lncRNAs.
However, this method cannot resolve the temporal spatial functions of such sequences.
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