Sentence examples for resolve the cellular from inspiring English sources

The objective of this study was to determine whether suppression/reduction of COMP expression could resolve the cellular chondrocyte pathology.

In light of these data, there is now an urgent need to determine whether exposure of human spermatozoa to RF-EMR can also induce DNA damage and to resolve the cellular mechanisms involved.

To resolve the cellular hierarchy, proliferation kinetics, and fate potential in the trachea, we used a biophysical modeling approach.

While the relatively coarse steps (0.15 mm) of the scanning XRF instrument do not resolve the cellular localization of Zn or Fe, non-destructive XRF technology allows for intact tissue samples to be recovered, re-embedded in paraffin, sectioned, and stained for class-III-β-tubulin, Zip14, and ferritin.

Apoptotic cell (AC) clearance is therefore important for resolving the cellular consequences of normal development during embryogenesis, and for cellular proliferation and differentiation that continues throughout life.

Resolving the cellular fate of such radiopharmaceuticals remains challenging due to the spatial limitations of SPECT, thus there is a drive to develop novel probes with fluorescent tags in order to facilitate high-resolution imaging by fluorescence microscopy.

We anticipate that our single-cell analysis method will help resolve the complex cellular pathways underlying disease by overcoming the limitations of averaged cellular measurements, where responses that appear to be coordinated based on co-expression at the population level may in fact be unrelated at the single-cell level.

Indeed, recent work has continued to resolve the unique cellular lineages, and causative pathways responsible for ectopic bone development yielding promising avenues for the development of novel therapeutic strategies shown to be successful in analogous animal models of HO development.

In view of the cancer prone phenotype associated with inactivation of the human MUTYH gene, it is tempting to speculate that the inability of Mutyh - defective mice to properly resolve the acute cellular response to external inflammatory stimuli and the consequent chronic persistence of the response might also plays a role in colorectal carcinogenesis in humans.

To study the function of the selected 18 lincRNAs in vivo and to resolve, at the cellular level, their expression pattern in different organs, we generated knockout mouse strains for each candidate by replacing the lincRNA gene with a lacZ reporter cassette ('Materials and methods', Figure 1 figure supplement 2 for details) (Valenzuela et al., 2003).

This entails resolving the physiological, cellular and molecular processes underlying the complexity of breast tumor development and associated tumor heterogeneity.