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Large sample sizes and deeper resequencing are much needed in resolving clinical and biological relevance of the mutations as well as in detecting somatic variants in heterogeneous samples and cancer cell sub-populations.
There has to be clinical need".
Determining whether the multiple resistance phenotype switching is due to cross-infection from neighboring patients or from natural mutation of the same A. baumannii isolate is important because of the different strategies needed to resolve the clinical issues.
Resolution of this issue is not possible in this study owing to limited power, so larger or longer studies are needed to fully resolve this clinical question.
Whether the antiviral immune response will allow for effective cancer therapy will need to be resolved in clinical trials.
However, multiple limitations were identified within the existing literature that need to be resolved before clinical recommendations can be made.
In addition, nurses' experiences of ethical violations in the clinical setting need to be identified before they can be resolved [ 34, 35].
Discrepancies were resolved by clinical judgment.
Further prospective studies are needed to resolve these important clinical questions.
An appropriately powered and clinically relevant randomised, controlled clinical trial is needed to resolve these issues.
All resolved without the need for surgery.
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CEO of Professional Science Editing for Scientists @ prosciediting.com