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Key to the success of these studies is the accuracy of the allelic frequency calculations, the ability to identify false-positives arising from assay variability and the ability to better resolve association signals through analysis of neighbouring SNPs.
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Indel rs3842715 in intron 14 was subsequently added to the SNP panel to resolve associations with rs2413396 as noted below.
Functional redundancy in odorant recognition among peripheral chemoreceptors may obscure the effects of individual polymorphisms on phenotypic variation, requiring large effect sizes and large sample sizes with sufficient statistical power to resolve associations.
This more direct relationship with underlying genetic diversity might account in part for the success of approaches resolving association with transcription of sequence variants, such as eQTL mapping [ 3, 5].
Since GWAS typically resolves associations to credible intervals that may contain from a few to a hundred or more candidate SNVs39,40, it has been proposed that algorithmic incorporation of functional and evolutionary scores might resolve true causal variants27,28,29.
The location information of identification sensors and objects is utilized to resolve the association problems with the object dynamics.
Further genotyping in large datasets is required to confirm and resolve this association.
Our ability to resolve this association strengthened when these variables were considered.
We have previously shown that tagging SNPs capturing the linkage structure defined by physical position 88,901,306 to 88,916,775 are adequate to resolve an association with obesity-related dylipidemia [4].
Given the location of ZFP57 in the MHC class I region, we sought to resolve the association and investigate the relationship with disease.
To resolve additional associations, we performed a joint-linkage-assisted genome-wide association study (GWAS) across RILs of the NAM and IBM families (Table 3, Table S6, Figure S3).
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