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Our primary structural data confirm and correct our previous sequence of the cDNA, establish the spatial relationship between zipper and unzipped (the gene originally thought to have been disrupted in zipper mutations), and provide a high resolution template for the precise mapping of mutations.
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Also, acetylcholine-binding proteins from mollusks, as structural surrogates of the receptor that mimic its extracellular domain, provide atomic resolution templates for analysis of structure and response.
Otherwise, the system works likely as you'd expect it to, checking against stored profiles for possible matches (and using stored lower resolution templates based on variables like different angles to make it more likely to correctly ID your finger).
Using the same set of 1996 images used by the city for NYCMap, the partnerships has fashioned a database, called Oasis, that deploys powerful mapping software to create a high-resolution template of the city, layered with reams of geographic data.
The method, combining the advantages of image segmentation and atlas-based approaches to generate a high-resolution template, is based on the widely available SPM8 software and provides robust and accurate linear attenuation coefficients (LACs) for head while requiring minimal user interaction.
A fundamental role of the M system/dorsal stream might be to produce a low-resolution template of the visual scene that influences perceptual processes, such as categorization of natural images, object recognition, and perceptual grouping in the ventral occipito-temporal cortex, by allowing P pathway fine-detailed input to be used more effectively (3,75 80).
To obtain favorable resolution for template matching, we symmetrically pad (crop) the rows/columns of I x, y) to the size of 1,024 if the height/width, H/W, is smaller (larger) than 1,024.
The C-terminal region of Ska3 was modelled as a GLEBS motif using the X-ray structure of the yeast Bub1-GLEBS/Bub3 at 1.9 Å resolution as template (PDBId 2i3s, chain B; Larsen et al, 2007).
The anatomical whole brain 3D T1-weighted images were corrected for intensity inhomogeneity (Sled et al., 1998) and a non-linear transformation towards the new high resolution ICBM template (Fonov et al., 2011) was calculated using a non-linear registration algorithm (Avants et al., 2008).
The N-terminal region of Ska1 was modelled as a Spectrin repeat-like fold using the sequence structure alignment obtained from threading and the X-ray structure of SNARE Tlg1 at 2.05 Å resolution as template (PDBId 2c5k, chain T; Fridmann-Sirkis et al, 2006).
Although the design was based on a low-resolution structural template, the resulting high-resolution NMR structure agrees remarkably well with the recent crystal structure of the TM domains of the bacterial Gloeobacter violaceus pentameric ligand-gated ion channel (GLIC), demonstrating the robustness and general applicability of the approach.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com