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We determined the crystal structures of the m3MST complexes with 1 and 3 at high resolution (Supplementary Table S3).
We applied 96 mV to the galvo mirror (4 steps), resulting to 5-ms time resolution (Supplementary Fig. 11b).
We obtained crystals of PCNA dsDNA complex with one PCNA trimer per asymmetric unit and diffracting to 2.8 Å resolution (Supplementary Table 1).
Using our modified library generation method, we generated genome-wide DNA methylomes for human sperm, oocytes, 8-cell embryos, morula, ICM, and 6-week embryos as well as the full-term placenta at single-base resolution (Supplementary Table S1).
Also, RvD1, PD1, and AT-LXA4 at 300 ng per mouse (i.e., 12 μg kg−1) each reduce the Ri, whereas RvE1 accelerates the onset (Tmax) of resolution (Supplementary Table 2).
Phases calculated from datasets collected at or near the zinc X-ray absorption edge ultimately yielded structures for two different crystal forms in the space groups P41212 (1.75 Å resolution) and P21 (1.55 Å resolution) (Supplementary Table S1).
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First, we found that population coupling at 250 ms resolution was highly correlated with that computed with different time resolutions (Supplementary Fig 5a, ρ = 0.97 for 100 ms, ρ = 0.93 for 50 ms, ρ = 0.77 for 10 ms, all p < 10 10).
For further investigation of resolution see Supplementary Figs S7 and S8.
We defined the structural relationship of tandem DUF26 domains by determining crystal structures of AtPDLP5 (residues 26 241) and AtPDLP8 (21–253) ectodomains to 1.25 and 1.95 Å resolution, respectively (Supplementary Table 1).
There was no significant difference in mean prediction abilities for single-family analysis between 1-cM and 0.2-cM resolution maps (Supplementary Figure S3).
Experimental phases for the CL1 and BAI3 structures were independently obtained from sulphur and iodine single anomalous diffraction (SAD) data at 1.9 and 2.3 Å resolution, respectively (Supplementary Table S1, Materials and methods).
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