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They found it remarkable that the overall model validation was improved only through changes to the spatial resolution of the assignment step, without modifications to the model design.
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Cβ resonance frequencies of three unperturbed correlations (F184, F185 and Y230), indicated by a horizontal line, are unresolved to within the 0.2 ppm/point resolution of the Cβ assignment spectra, and are not assigned.
Through the concatenation of the gene sequences from two lamprey species, full length ABC transporter sequences were obtained, which significantly improved the resolution of the name assignment and phylogenetic position for the genes compared with a previous analysis in which sequence fragments were used.
However, low resolution of the X2 haplogroup assignment in the latter study prevented us from drawing more conclusive phenotypic association of the G15927A variant.
We admit that the limited model resolution and the assignment of homogenous parameters to the layers are likely to be a source of error in our approach.
Albeit, we admit that the limited vertical and horizontal resolution, the assignment of uniform physical properties to most of the layers and the prescribed first kind boundary conditions may be sources of error in our results.
Due to the heterogeneous resolution of haplogroup assignment among populations, forming a non-relevant database, only the admixture rates of continental populations (European, Amerindian and African), given in published studies, have been considered.
However, the low resolution of the MS/MS datasets makes assignment of modifications, including crucially the site of modification, less confident and ill suited for routine use.
We showed that the resolution of conflicting assignments clearly improves the BFS-method.
Thus, to better understand the functional potential of nodal mutations (both RNMs and SNMs) future mtDNA disease-association studies will benefit from higher resolution of haplogroup assignment.
However, the resolution of the structure does not allow unambiguous assignment of the proline puckers.
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