All of these refinements allow improved resolution of pathways involved in metabolism in our model.
The modular enrichment analysis executed directly with all the differentially expressed genes, improved the resolution of the pathway analysis, co-occurrence annotations were found with low significant P values for: pathways in cancer, focal adhesion, T cell receptor signaling, angiogenesis, and MAPK signaling.
Such analytical combination provides critical information for the resolution of central pathways [ 19].
As in infected cardiomyocytes [ 38], this balance could also determine the activation of DDR seen in infected epithelial cells and also the resolution of these pathways leading either to senescence, DNA repair, or apoptosis.
Using breast cancer and its four primary clinically relevant subtypes as examples, this approach is evaluated based on the reproducibility, accuracy and resolution of the resulting pathway profiles.
Consequently, we hypothesized that inclusion of this epigenetic information into large-scale association studies may yield an even finer resolution of the biological pathways underlying platinum sensitivity.
These observations indicate that despite having a variety of enzymes capable of HJ resolution, pathway usage in mitotic cells is biased to favor STR/BTR-mediated dHJ dissolution and NCO formation.
DTI has provided excellent resolution of the major fiber pathways involved in speech, vision, and motor functions.
This resolution of inflammation and the pathways involved in restoration of uterine homeostasis have not been extensively explored in healthy cows.
Unlike yeast which predominately uses a high-fidelity HR to repair DSBs [48], mammalian cells employ two distinct mechanisms for the resolution of DNA DSBs: the main pathway, non-homologous end-joining (NHEJ), and the other, the HR pathway [49].
