There is a suggestion that pulsed-dose methylprednisolone, in addition to aspirin and IVIG as primary therapy results in faster resolution of fever, more rapid improvement in inflammatory markers, and shorter length of hospitalization.
Conclusions Treatment of acute KD with IVMP plus ASA/IVIG, compared with ASA/IVIG alone, resulted in faster resolution of fever, more rapid improvement in markers of inflammation, and shorter length of hospitalization.
Conclusions: Early treatment of KD resulted in less coronary ectasia at 1 year after KD onset but was not associated with a quicker resolution of fever, an increased number of treatment failures, an increased need for adjunctive therapy, length of hospitalization, nor development of coronary artery lesions.
All patients experienced resolution of fever, with ten being lost to follow-up.
Secondly, the new primary outcome recommended measuring cessation of the spread of lesion erythema, edema, or induration, in addition to resolution of fever, whereas previous guidance recommended investigator-determined clinical response or 'cure'cure
Compared to the control patients, the Altastaph recipients had a shorter median time to the resolution of fever (2 days and 7 days, respectively; P = 0.09) and a shorter length of hospital stay (9 days and 14 days, respectively; P = 0.03).
Dosage regimens producing Cmax concentration within a range of 5 to 8 mcg/ml for TMP and 100 to 200 mcg/ml for SMX have been demonstrated to produce more rapid resolution of fever and improvement of alveolar-arterial oxygenation gradient than use of pentamidine [13].
There was no significant difference in the resolution of fever (FCT) between the two treatment groups (Table 2).
Secondary outcomes included resolution of fever, parasite clearance, change in haemoglobin level, presence of gametocytes during follow-up, and the occurrence of adverse events.
The PCT decrease below 500 pg/mL preceded the resolution of fever: median 5 days (range 1 23) vs. 10 days (range 3 22), respectively (p = 0.026).
Moreover, a PCT decrease to normal levels significantly preceded the resolution of fever in follow-up of IFD responding to antifungal therapy.
