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Together, these data provide evidence that SIRT6 KD leads to impaired resolution of DNA DSBs and increased accumulation of broken DNA.
Resolution of DNA double-strand breaks (DSBs) is essential for the suppression of genome instability.
Matos, J., Blanco, M., Maslen, S., Skehel, J. & West, S. Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis.
Collectively, these data indicate that high levels of MYC proteins delay the resolution of DNA lesions engineered to occur in cell cultures.
Thus, Ku is an essential component of the pathway(s) utilized for the resolution of DNA double-strand breaks induced by either X rays or V(D J recombination, and mutations in the Ku86 gene are responsible for the phenotype of group 5 cells.
Today, the sensitivity, dynamic range, and resolution of DNA microarrays are limited by interference, noise, probe saturation, and other sources of errors in the analyte detection procedure.
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Radiosensitization by T-oligo was associated with increased formation and/or delayed resolution of γH2AX DNA damage foci and fragmented DNA.
Pinkel, D. et al. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays.
Second, we generated single-base resolution maps of DNA methylation using whole-genome bisulfite sequencing.
Here we generated whole-genome, single-nucleotide resolution maps of DNA methylation in several regenerated rice lines.
The accurate and high resolution mapping of DNA copy number aberrations has become an important tool by which to gain insight into the mechanisms of tumourigenesis.
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