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Coe, B.P. et al. Resolving the resolution of array CGH.
The resolution of array CGH is determined by the size and number of the clones placed on the array to interrogate genome copy number changes.
Compared to conventional CGH, the significantly improved resolution of array CGH permits highly accurate mapping of DNA copy number changes throughout the genome.
The resolution of array CGH technology combined with human genome database suggested the possible target genes present in the gained or lost clones.
Aberrations restricted to small chromosomal regions were also frequently observed, which may be attributed to the increased resolution of array CGH compared with LOH and metaphase CGH.
The resolution of array CGH technology combined with human genome database not only allowed a precise identification of amplicons but also suggested the possible target genes within the amplicons.
Similar(53)
Advances in the resolution of array-CGH technology allow specific identification of genomic breakpoints.
Because of this disadvantage, it is thought to combine with SNP arrays to improve the resolution of array-CGH [ 37].
The resolution of array-CGH, though extremely costly, can be improved by using high-resolution whole-genome tiling arrays.
This formula shows that the copy number resolution of array-CGH (difference in ANILFR between two regions of consequent copy number) is inversely proportional to the ploidy level.
In contrast, the resolution of array-CGH is limited only by the density and average length of the probe set printed on the array.
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