However, current PPI databases only provide low-resolution knowledge of PPIs, in the sense that "proteins" of currently known PPIs generally refer to "genes".
Such high-resolution knowledge about the genetic events that drive individual steps of metastasis will be imperative for a more in-depth understanding of cancer progression, as well as for improved design of prognostic and therapeutic tools for breast cancer.
The study yielded an increased spatial resolution to knowledge of water-quality variability in the urban environment compared to previous studies within the YRD region.
Compared to a linkage gene set network (L-GSN), which is constructed from protein interactions discarding directionality of the interactions, an R-GSN provides higher resolution of knowledge.
Interactions and collaboration between stakeholders depend on various social factors, such as trust, conflict resolution, and knowledge integration [ 6], and also on circulation of information within social networks [ 7, 8].
Next, to the limits of the resolution of knowledge of phylogeny of mammals of Africa and Asia, we sought clades with geographic distributions that coincided with those of the African filoviruses.
Conflict resolution, marketing knowledge, technical skills and employee management are a few of the areas that may need further development.
To cope with the ill-posed nature of image super-resolution, prior knowledge of natural images is usually employed for regularizing the solution to the following minimization problem: mathbf{X} = underset{mathbf{X}}{text{argmin}}, ||mathbf{Y} - SHmathbf{X}||^{2}_{2} + lambda J mathbf{X}) (2).
To improve low-resolution refinement, knowledge from macromolecular chemistry and homology was used to add three new coordinate-restraint functions to the refinement program phenix.refine.refine
The only high-resolution structural knowledge of GPCR-G protein interactions is from the β2 adrenergic receptor-G protein complex structure solved by Rasmussen et al. [8], and the crystal structure of agonist-bound NTS1 was solved only recently [9].
