Resolute and Endeavor zotarolimus-ES, everolimus-ES, and sirolimus-ES, but not biodegradable polymer biolimus-ES, were associated with significantly reduced odds of myocardial infarction (by 29-34%) compared with paclitaxel-ES.
According to LinkedIn, AngelList, and CrunchBase, the startup has an undisclosed amount of seed funding from Khosla Ventures, Resolute Ventures, Curious Endeavors, Marc Bell Ventures, and other angels.
According to LinkedIn, AngelList, and CrunchBase, the startup has an undisclosed amount of seed funding from Khosla Ventures, Resolute Ventures, Curious Endeavors, Marc Bell Ventures, and other angels.
In light of these findings, the safety and efficacy of the biodegradable polymer devices compared with first generation paclitaxel-eluting stents (paclitaxel-ES) and sirolimus-ES, and with second generation durable polymer Endeavor and Resolute zotarolimus eluting stents (zotarolimus-ES) and everolimus-ES, are currently unclear.
The following keywords were used: "randomised trials", "drug-eluting stent", "sirolimus stent", "paclitaxel stent", "everolimus stent", "zotarolimus stent", "Endeavor zotarolimus-stent", "Resolute zotarolimus-stent", "biodegradable polymer stent", "bioabsorbable polymer stent", "biolimus stent".
CABG=coronary artery bypass grafting; MI=myocardial infarction; PY=patient years; PTCA=percutaneous transluminal coronary angioplasty; BMS=bare metal stent; DES=drug eluting stent; PES=paclitaxel eluting stent; SES=sirolimus eluting stent; R-ZES=zotarolimus eluting (Resolute) stent; E-ZES=zotarolimus eluting (Endeavor) stent; EES=everolimus eluting stent.
We included first generation durable polymer sirolimus-ES and paclitaxel-ES; second generation durable polymer everolimus-ES, Endeavor zotarolimus-ES, and Resolute zotarolimus-ES; and biodegradable polymer biolimus-ES.
CABG=coronary artery bypass grafting; PTCA=percutaneous transluminal coronary angioplasty; BMS=bare metal stent; PES=paclitaxel eluting stent; SES=sirolimus eluting stent; E-ZES=zotarolimus eluting (Endeavor) stent; R-ZES=zotarolimus eluting (Resolute) stent; EES=everolimus eluting stent.
In the meantime, to support its mission in Japan and acquire the fuel it needs for launch and its first months in its new home, OKpanda has raised $1.4 million in a round led by Resolute Ventures, with participation from firms like Innovation Endeavors, Kapor Capital and 500 Startups.
As seen with the one year outcomes, in comparison with paclitaxel-ES, Endeavor zotarolimus-ES, everolimus-ES, and Resolute zotarolimus-ES (similarly to sirolimus-ES) provided a 31-37% significant decrease in myocardial infarction.
The Resolute ZES (R-ZES) uses the same antirestenotic drug as the Endeavor ZES (E-ZES) but has a more biocompatible polymer with enhanced drug release kinetics.
