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Efforts to find effective drug combinations for people with highly resistant viruses are called salvage therapy.
The resistant viruses did not spread to anyone else.
Such patients are more likely to develop resistant viruses when on Tamiflu because they can not clear a virus on their own.
Passage with a higher drug concentration of compound 2 selected higher level resistant viruses with a double mutant L26I + A30T.
Also unanticipated was the persistence of resistant viruses to the present day, despite minimal use of adamantanes (9).
We have attempted to select for RAL resistant viruses in culture for several months now, and have not yet been successful at isolating drug resistant viruses.
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Naturally occurring drug-resistant viruses (i.e. resistance in viruses that have not been subject to selective drug pressure) are rare.
It has a high genetic barrier to resistance and is active against nevirapine- and efavirenz-resistant viruses.
Also, they say, self-prescribing may lead to waste of the drugs or misuses that spur the growth of drug-resistant viruses.
However, the sustainability of such regimens remains unclear, particularly for patients infected with multidrug-resistant viruses.
One of the most important negative effects is the potential for emergence of vaccine-resistant viruses.
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