These substrate-envelope violation volumes are calculated to be a little higher than those for amprenavir (3.73 Å) or darunavir (4.10 Å) that have low susceptibility to drug-resistant variations but are much lower than those for drugs with high susceptibility, such as saquinavir (80.40 or 64.73 Å; PDB accession code 3OXC 28) [A or B]).
tbvar provides an annotation feature 'annoTB', where users can input custom variant list from re-sequencing data, and annotate them for potential drug-resistant variations, retrieve allele frequencies of variations, genomic variations in regulatory regions and also retrieve information on other strains that have the same variation.
When the 34F2_AP50R WGS data were compared to the parent 34F2, we found two high confidence variations in the phage resistant mutant (Table 3).
In the past, those dynamics are considered to be inherently Darwinian in character in which clonal destruction inadvertently enables selection pressure for the expansion of treatment- resistant clonal variations.
Although spatial selectivity is found in both anterior and posterior belt areas of the monkey auditory cortex, the number of spatially selective neurons is greater and the spatial receptive fields are more resistant to variations in sound level in the posterior areas [38], [48], [49].
This imaging-based nanohole biosensing method is extremely robust and highly resistant to variations and defects in the nanoholes resulting from imperfect fabrication.
Slope extrapolation makes the AO correction more stable and resistant to variations arising from slight head motions and pupil size change.
To find out whether certain types of PTM or other functional sites are resistant to variations, P-values were calculated based on methods described earlier (24, 52), to estimate the significance between observed and expected numbers.
The GluN2 subunit in this quaternary arrangement has a greater probability to retain the l-Glu agonist in its cleft and hence would be more resistant to variations in the neurotransmitter concentrations.
In contrast to the same substitutions in the structurally related blue copper azurin, much smaller changes (∼20 mV) in reduction potential were observed, indicating that the diamond-core structure of the CuA site is much more resistant to variation in axial ligand interactions than the distorted tetrahedral structure of the blue copper protein.
