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No DFF45/ICAD-deficient mouse has shown any developmental abnormality, but some cell types have shown reduced DNA fragmentation and DNA condensation and are partially resistant to undergo apoptosis (Zhang et al, 1998, 1999).
An additional goal in our study was to determine whether serum-induced apoptosis in Jurkat cells is specifically mediated by the CD95 pathway, this objective was met by using the CD95 resistant JurkatR cell line (Fig. 3); these cells were resistant to undergo apoptosis after incubation with different sera that were able to induce apoptosis in Jurkat cells.
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Inactivation of CAD has been shown to render cells resistant to undergoing apoptosis (Sakahira et al, 1998) and may cause cell transformation.
The results in Figure 6 refer to the cumulative mean values of three experiments performed and show that U937Bcl-2 were highly resistant to undergoing apoptosis even after treatment with high concentrations of 𝒟lentiginosine.
As shown, small interfering RNA (siRNA -mediated knockdown of PI3K, primarily targeting the p110 catalytic siRNA -mediatediggered resistant cells to undergo apoptosis, as indicated by increased expression of cleaved PARP and significant inhibition of cell growth and viability (P < 0.0058).
To determine whether TAM can act cooperatively with α-TEA to trigger TAM-resistant cells to undergo apoptosis, we examined the combination effect of three nonapoptotic doses of tamoxifen (0.5, 1, and 1.5 μ M) with three sub-half-maximal effective concentration (EC50) apoptotic doses of α-TEA (10, 20, and 30 μ M) on induction of apoptosis.
The chances of live birth in women with WHO Group II anovulatory infertility resistant to CC undergoing ovulation induction with gonadotrophins is highly influenced by the menstrual cycle pattern.
Fifty-nine patients with treatment-resistant depression scheduled to undergo ultra-brief right unilateral ECT were randomly assigned to either: (a) Mem-ECT, (b) active control comprised of nonspecific mental stimulation, or (c) treatment as usual.
Therefore, ART can induce the Doxorubicin-resistant CEM cells to undergo apoptosis.
Therefore, ART can overcome the Doxorubicin-resistance and induce the Doxorubicin-resistant leukemia cells to undergo apoptosis.
In vivo, radiation-sensitive tissues respond to DNA-damaging treatments with mitochondrial localization of p53 and rapid apoptosis, whereas radio-resistant tissues fail to undergo these processes.
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