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Tchaikovski and co-workers investigated mechanisms whereby AGEs and RAGE expression inhibit the response of circulating macrophages and progenitor cells to promote angiogenesis in limb ischemia in diabetes and found activation of VEGFR-1-related signal transduction pathways in monocytes making them resistant to stimulation by VEGF-A [6].
Clearly our data shows that hESC are resistant to stimulation with PAMPs except for flagellin.
These lowGM-DC remained at their immature state and were resistant to stimulation with TNF, LPS or CD40 ligation [23].
In this study we observed that in obese individuals the brain appears to be resistant to stimulation of beta- and theta-activity by insulin.
It has been reported that worms carrying egl-30 loss- or gain-of-function mutations showed opposite egg-laying phenotypes, but were both resistant to stimulation of egg laying by 5-HT treatment [30].
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Moreover, similarly to what observed under cell-free conditions, RRASG39dup was resistant to GAP stimulation.
This is in agreement with other reports showing that H1299 cells are resistant to ligand stimulation of the death receptor pathway.
They are resistant to mitogenic stimulation and exhibit pH-dependent β-galactosidase activity (Johnson and Longenecker, 1982; Dimri et al., 1995).
Although EVT are relatively resistant to apoptotic stimulation, we have previously shown that inhibition of NO synthesis can increase their sensitivity to members of the TNF superfamily, including TRAIL (Dash et al., 2007).
Aortic smooth muscle cells from transgenic animals showed significant upregulation of TGF-β responsive genes important for cytoskeletal function, such as transgelin and smoothelin, which were then resistant to further stimulation with exogenous TGF-β1.
Rats chronically (7 10 days) infused with insulin while maintaining euglycaemia became markedly resistant to the stimulation of glucose uptake and suppression of plasma NEFA by insulin [ 23], and became hypertensive [ 33].
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