Sentence examples for resistant to reverse from inspiring English sources

MDH-1-38 aNS1040040 remained equally active in human PBMCs in the presence of added serum proteins as well as against HIV-1 isolates resistant to reverse transcriptase, integrase or protease inhibitors.

Vertical transmission of HIV-1 variants resistant to reverse transcriptase inhibitors has been reported and some studies suggest that resistant mutations are selectively transmitted [3] [5].

Our studies demonstrate that both SPL7115 and SPL7013 are HIV entry inhibitors with broad-spectrum anti-HIV activity against a wide range of X4 and R5 clinical isolates, different HIV-1 clades, early R5 clinical isolates, HIV-2 and a HIV-1 strain resistant to reverse transcriptase and protease inhibitors.

Results of this study indicated a potential for RGD/TAT-functionalized virus-like micelles as promising carriers for efficient delivery of mdr1 siRNA to MDA435/LCC6 resistant cells as means to reverse the P-gp mediated multidrug resistance to DOX.

And while crops engineered to manufacture an insect-killing toxin have reduced the use of pesticides in those fields, the emergence of newly resistant insects now threatens to reverse that trend.

Our findings may open an avenue toward the development of new therapeutic rationales designed to reverse resistant cell states.

"We have figured out a way that tumor cells become resistant to existing therapies and a way to reverse that resistance".

In order to reverse the resistant phenotype in cell cultures, we constructed a specific hammerhead ribozyme possessing catalytic activity that cleaves the 3'-end of the GUC sequence in codon 880 of the mdr1 mRNA.

Therefore, we believe that the regulation of NF- κB is also a feasible way to reverse drug-resistant epilepsy, and this method also provides a clinical basis for the anti-inflammatory treatment of drug-resistant epilepsy.

Seven vertically infected children and adolescents who had previously failed highly active antiretroviral therapy and were resistant to nucleoside reverse transcriptase inhibitors, received a dual protease inhibitor (PI) regimen including fAVP plus ATV/r for 42 months.

We observed that NSC23925 was unable to reverse drug resistance in these non-Pgp1 expressing drug resistant cell lines, suggesting that NSC23925 activity is specific for Pgp1.