Macrophages are fairly resistant to apoptosis, as interaction with some bacterial pathogens and/or their toxins induces only limited apoptosis in these cells [21], [33].
We found that Institutional Review Boards are generally unfamiliar with CBPR, reluctant to oversee community partners, and resistant to ongoing researcher-participant interaction.
Interestingly, Ross-Innes et al. observed that, in tumors resistant to endocrine therapy, ER interactions were enriched with FOXA1 motifs (Ross-Innes et al. 2012).
For example, functionally diverse communities can be more resistant to invasions because some trophic interactions stabilize otherwise dominant competitive interactions within the community21.
We further extended the analysis in vivo, demonstrating that endogenous CAF1 interacts with MIWI in adult mouse testes and their interaction is resistant to RNase A treatment.
We also confirm that PLK1 physically interacts with DNA-PKcs in mitosis and show that this interaction is resistant to inhibition of either DNA-PKcs or PLK1 therefore is not mediated by phosphorylation of either protein.
Thyme et al. find two reasons: some short stretches in the genome are resistant to CRISPR/Cas9 cleavage, and intramolecular interactions within guide RNAs can interfere with the ability of guide RNA-Cas9 complexes to generate double-strand breaks in DNA.
We show that if HMT is quite resistant to direct photolysis under vacuum, interactions with water vapor photoproducts, which could happen in inner comae, lead to a much more efficient degradation with formation of HCN, NH3 and other N bearing molecules.
Furthermore, the interactions were resistant to RNase treatment, indicating that both proteins are part of the same complex (Additional file 1: Figure S1B).
In contrast to the same substitutions in the structurally related blue copper azurin, much smaller changes (∼20 mV) in reduction potential were observed, indicating that the diamond-core structure of the CuA site is much more resistant to variation in axial ligand interactions than the distorted tetrahedral structure of the blue copper protein.
The ATF1S36/41A mutant showed greater than four-fold higher binding affinity for the KIX domain when compared to wild-type ATF1, and the ATF1S36/41A-KIX interaction was completely resistant to the effects of IR (Fig. 2F).
