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Key: The profile of 26 patients in whom H. pylori infection was eradicated and 14 patients in whom H. pylori infection was resistant to eradication therapy are compared.
Despite efforts to find a cure, there are some ills within journalism that seem stubbornly resistant to eradication.
Several critical factors make sexual violence in conflict resistant to eradication.
When mature, the biofilms assume sessile forms, which are more resistant to eradication (Hoiby et al. 2011).
Furthermore, the ability of these organisms to form biofilms renders them resistant to eradication, even with aggressive therapy comprising frequent high-dose administration of intravenous antibiotics, such as aminoglycosides and β-lactams.
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In a murine model, it was observed that tumor cells transfected with IDO became resistant to immune eradication, even in mice in which a fully protective immune response had been established by immunization [ 45].
For the strains resistant to metronidazole, the pooled eradication rate was 86.4%; however, as in the previous case, sequential therapy achieved significantly better results only when compared with triple therapy lasting seven or 10 days.
16 A melanoma study showed that PDH inactivation by serine 293-phosphorylation by PDK led to high tumorigenic activity, whereas PDK depletion resulted in hypophosphorylation of PDH, regression of tumors, and further eradication of subpopulations resistant to a specific inhibitor to oncogene BRAF,V600E(17) which suggested an exclusive dependency on aerobic glycolysis of melanoma growth.
The phenotypic diversity of disseminated cells resulting from intra-tumor heterogeneity [ 1, 2] gives rise to clones resistant to chemotherapy and prevents tumor cell eradication by chemotherapy.
Furthermore, these cells are thought to be inherently resistant to various therapeutic drugs, making the eradication of tumors containing cancer stem cells with the use of the current treatment protocols difficult [ 5].
If we consider the studies that could not be included in the meta-analysis (our criteria required at least three comparable study groups for every comparison), the modified levofloxacin based sequential therapy showed eradication rates of about 90% and was able to achieve a high eradication rate in strains resistant to clarithromycin, metronidazole, or both.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com