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Also, 83% of PP isolates were resistant to C (≥ 32 ug/ml), while recent EP and NEP isolates were susceptible.
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In addition to Al, the mutant was also more resistant to Cd than WT.
These results revealed that the mutant was also more resistant to Cd. Fig. 4 Sensitivity to other metals.
Since ral1 mutant was more resistant to Cd as well, we want to know whether Cd accumulation pattern in the mutant was altered or not.
BT-20 cells that express high levels of BRCA1 levels were most resistant to C-1305 than other tested cells.
The cell lines that have not been modified were selected as they are not abnormally prone or resistant to C-Frag.
To facilitate our investigation, we studied two melanoma model cell lines (MU-P and RU-P) that are known to express high levels of p-c-Met, which we made resistant to c-Met TKIs by exposure to sequentially increasing doses of the c-Met inhibitor SU11274.
Subjects who are living in highly polluted areas may become somewhat more resistant to Cd toxicity than those in slightly polluted areas.
As expected, the Δslr1738 mutant was found to be less resistant to Cd than the WT strain (Fig. 5B and 5D), indicating that Slr1738 mediates some of the Cd-elicited regulations.
BT-20 cells with strong expression of BRCA1 were resistant to C-1305 whereas MCF-7 cells and SKBr-3 cells were more sensitive.
First, ABCG2-overexpressing A549/K1.5 cells that displayed a marked increase in the number of lysosomes were 2.4-fold more resistant to C-1330 and C-1379, both of which are not recognized as drug efflux substrates by ABCG2.
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