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aSpecies and synthetic allopolyploids are referenced by their sections within the genus Nicotiana, primary location of origin, and their haploid chromosome numbers according to [ 10]. bCategories of resistance (1, most resistant, through 6, most susceptible) are indicated for each virus-host combination tested.
The current strategy to overcome acquired resistance involves molecular profiling of the resistant tissue, either from a relapsed patient or from in vitro or in vivo models that have been made resistant through chronic exposure to drug, in hopes that resistance factors can be identified and pharmacologically targeted.
Weeds became resistant through evolution.
We assess different two-dimensional surface conductance models and vary the underlying 1D conductivity models to simulate the effects of resistant through to conductive lithosphere.
A2780cisR cells are resistant through a combination of reduced drug transport enhanced DNA repair/tolerance and elevated glutathione (GSH) levels with respect to the parental A2780 cells.
Our results also provide the proof-of-principle that cells can be rendered HIV resistant through single-copy vector transduction, rendering this approach more compatible with clinical applications.
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Perry said that, if analyzed correctly, there should be a way to produce plants that are insect- and pest-resistant through the use of microbes, which could help assuage consumers to buy produce yielded through Indigo coatings.
Mice that overexpress the resistin gene (retn) in the liver are insulin-resistant through increased levels of serum resistin [3], while mice without retn show decreased fasting plasma glucose levels [4].
For this, we generated an MCF-7 derivative cell line that is tamoxifen-resistant through enhanced PKA activity.
While the reasons for this result are unclear, it is possible that the cells have become drug-resistant through means other than the MDR machinery, such as upregulation of one or more anti-apoptotic proteins, and thereby rendered forced expression of Bcl-2 incapable of rescuing cells further.
Identifying genetic markers of resistance could help in artificial selection of resistant lines through breeding strategies.
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