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If general, this has important implications for targeted JAK2 inhibitors as remitting rather than curative therapeutics due to the existence of a resistant reservoir of MPN-initiating cells [48].
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In Panama (10 ) and Florida (5, 7 ), S. hispidus rodents are considered to be competent, mostly disease-resistant reservoir hosts for disease caused by sympatric VEE complex alphaviruses.
Furthermore, the presence of abnormalities in the lymphocyte compartment confers an unfavorable prognosis for affected patients, either because is reflective of a more aggressive disease and/or because this compartment represents a drug-resistant reservoir of CSC that maintains the disease.
The company's inventory offers accessories designed just for soldiers -- drinking tubes and spouts that can be used with a gas mask, a chemical-resistant water reservoir, an in-line filter for cleaning water supplies as the users drink it.
High frequency of fusidic acid resistance may persist despite such restrictions and may represent the development of a fusidic acid-resistant S. aureus reservoir in the community.
Without appropriate regulation, it is thought that a large diverse reservoir for resistant bacteria and resistance genes could facilitate the emergence and spread of resistant pathogens to humans, and even the ongoing transmission of such resistant organisms within the human population.
Two antimicrobial classes expected to provide the future therapeutic options for treatment of infections with vancomycin-resistant enterococci have analogues among the growth promoters, and a huge animal reservoir of resistant E. faecium has already been created, posing a new public health problem.
The reservoir of resistant bacteria in food animals implies a potential risk for transfer of resistant bacteria, or resistance genes, from food animals to humans.
These persisters act as a genetic reservoir for resistant mutants and constitute a root cause of antibiotic resistance, a worldwide problem in human health.
Food animals are likely the primary reservoir of resistant S. Typhimurium.
Campylobacter in poultry house water distribution systems is another potential reservoir of resistant strains.
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