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Potentially genetic disruption of the P-gp encoding genes may induce upregulation of other transporters (i.e., multidrug resistance protein 1, and breast cancer resistant protein (Bcrp 1), while chemical inhibition of P-gp function might also inhibit other transporters, such as Bcrp1, in the case of tariquidar [11].
One of the known causes of MDR is overexpression of the ATP-binding cassette (ABC) transporters, such as P-glycoprotein (ABCB1/P-gp), multidrug resistance proteins (ABCCs/MRPs) and breast cancer resistant protein (ABCG2/BCRP).
Although the multi-drug resistant protein transporter has been implicated in chemo-resistance, no mechanism has been proposed for irradiation resistance.
In tobacco, the NPK1-MEK1-Ntf6 cascade regulathe the resistance to the tobacco mosaic virus mediated the resistant protein N [ 28].
Some years ago, a new drug resistant protein, i.e., the breast cancer resistance protein (BCRP/ABCG2), which is the equivalent of the mitoxantrone (MXT) resistant protein and the placental ABC transporter (ABCP), was found to be expressed in AML [ 8– 13].
Human myxovirus resistant protein A (MxA), encoded by the myxovirus resistance 1 (Mx1) gene, is an interferon (IFN -triggered dynamIFN -triggereddomain GTPase involved in innate immune responses against viral infections.
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In addition, several MYCN target genes, including multidrug resistant protein-1 (Mrp1), sirtuin 1 (SirT1) and ornithine decarboxylase (Odc1), are associated with the onset and aggressiveness of disease.
Dr. Gabizon called that enzyme-resistant protein a urinary prion and said it was new.
Hung, C.-C. & Liou, H.-H. YC-1, a novel potential anticancer agent, inhibit multidrug-resistant protein via cGMP-dependent pathway.
HIS-tag in HIS HaPrP seems to have little effect on the formation of protease-resistant protein in this preparation.
multi-resistant protein.
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