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Several previous reports demonstrated that EMT characteristics might confer a chemo-drug resistant potential in tumor cells [ 10, 14].
A549 cells exhibiting the highest level of Cav-1 showed the strongest anoikis resistant potential in comparison to that of H23, H292, and H460 lung cancer cells, suggesting the role of Cav-1 in attenuating anoikis process in these cells).
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In hospital environments, a decreased colonization resistance and persistence of antibiotic resistance could potentially lead to an overgrowth and spread of multi-resistant potential pathogenic bacteria and thereby increase the risk of treatment failure.
Twist1 depletion in HLE cells surprisingly decreased proliferation, anoikis-resistant potential and phosphorylation of Akt, suggesting that the survival of HLE was largely dependent on Twist1 regulation.
On the other hand, there was no indication of any substantial induction of anoikis-resistant potential by Twist1 overexpression using PLC/PRF/5 and HuH7 (data not shown).
The results of the current study suggest, for the first time, that the CD44high population has anoikis-resistant potential, a property that is especially important for CTCs.
The rapid growth of tumor parenchyma leads to chronic hypoxia that can result in the selection of cancer cells with a more aggressive behavior and death-resistant potential to survive and proliferate.
Both control and doxorubicin-resistant MCF-7 cells did not noticeably generate fused cells when cultured in drug free condition, suggesting MCF-7 cells with doxorubicin-resistant potential are initiated from the drug induced cell fusion.
We speculate that although Twist1 probably contributes to mesenchymal phenotype and anoikis-resistant potential, it may do so only partially, requiring a collaborating factor in order to strengthen these characteristics.
This should make them theoretically more resistant to potential damage from elements like hail, or even debris like fallen tree branches.
Based on the analysis of the experimental data, a double-layer SEI film mechanism should be suggested and can well explain the mutation of the resistant and potential observed in the charge/discharge curves and EIS.
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