Sentence examples for resistant point from inspiring English sources

Together, our data confirmed the coexistence of the EGFR-activating mutation of exon 19 deletions or L858R, and the resistant point mutation of T790M or E545K before the TKI treatment.

For cell contraction assays, 5×10 of HMVEC-dLy cells were grown for over night on coverslips (Thermo Scientific) with fibronectin coating, then treated with 1 nM of alkaline phosphatase (AP) control protein, mouse AP-Sema3F with cleavage resistant point mutations (R580A/R582A), or mouse AP-SEMA3G for 30 min.

The MDSC-inducing fungal factor was present in conditioned supernatants and was heat resistant, pointing to β-glucans as the bioactive component.

However, accelerated or blast-crisis phase CML patients and Ph+ ALL patients often relapse due to drug resistance resulting from the emergence of imatinib-resistant point mutations within the BCR-ABL tyrosine kinase domain.

This indicates that the potential for new drug-resistant point mutations in BCR-ABL persists and justifies the continued development of more potent BCR-ABL inhibitors (Weisberg et al, 2007).

Based upon the in vitro data, this level of drug exposure would be expected to result in clinical activity against most of the mutants characterised in Table 1, with the exception of T315I, and is therefore consistent with the responses observed in patients harbouring imatinib-resistant point mutations.

It is a conventional belief that line-based approaches perform better than point-based ones for homography estimation, as the line-fitting is generally more noise resistant than point detection.

MICs of penicillin G and tetracycline persisted at high levels and the MIC90s were 32-fold higher than the resistant cutoff point over 11 years.

MIC90s of penicillin G and tetracycline already reached at least 32-fold of the resistant cutoff point and were largely in accordance with previous surveys conducted in Southeast Asia.

Without AZT, epistasis is consistently positive within the TZM-bl cell line and the PBMCs of both blood donors, and results in an estimated 1.5 to 2.8-fold increase in the ratio of the highly resistant 2-point mutant M41L-T251Y to wild type.

In addition, uniform accumulation of TPI (trypsin protease inhibitor) in resistant plants pointed towards the role of JA in regulating defense [ 51].