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Exposure of oncogenically-transformed mouse embryonic fibroblast cells to multiple rounds of hypoxia and aerobic recovery revealed the ability of hypoxia to select for p53-/ (apoptosis resistant) over p53WT cells.
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P. falciparum parasites bind to chondroitin sulfate A (CSA) to sequester in the placenta, and women become resistant over 1 2 pregnancies as they acquire antibodies that block adhesion to CSA.
In the present study, we observed a significant decrease in the frequency of the tc_ rph2 rr homozygous resistant genotype over 18 generations with a corresponding increase in heterozygote (tc_ rph2 rs ) and susceptible genotypes (tc_ rph2 ss ).
The extensively drug-resistant rates over 10 years stratified by these independent factors are shown in Figure 3.
Isolates belonging to clusters with at least two isolates with resistant members having the identical resistance pattern ("two-isolate resistant" clusters) were over 4 times more likely in the selective than in the universal DOT county (p < 0.0001).
Once thought to be particularly resistant to over-exploitation [17], an increasing number of historical [3], [4] and recent invertebrate fisheries [2], [5], [12] tell a different story.
In the interactions involving GMB4 with Jaya (susceptible host) and RP2068 (resistant host), over-expression of OoDAD1 was observed in both cases.
We found that the ARL1 COS-resistant over-expression strain was as sensitive to Amphotericin B, Fluconazole and Terbinafine as the wild type cells and that when COS and Fluconazole are used in combination they act in a synergistic fashion.
MICs of penicillin G and tetracycline persisted at high levels and the MIC90s were 32-fold higher than the resistant cutoff point over 11 years.
The 21 n M doxorubicin-selected clone was nearly four-fold more resistant to doxorubicin and over 90-fold more resistant to mitoxantrone (Table 1).
In the probe sets up-regulated in infected resistant CB46 over infected susceptible null- Rk, the most abundant classes were cellular transport (36.8%), proteins with binding function (21%), and proteins involved in transcription (15.7%).
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