Sentence examples for resistant neurons from inspiring English sources

Do resistant neurons compensate with other fission or fusion mechanisms?

This apparently inconsistent result can be explained by the fact that total mRNA was extracted from the remaining, more resistant neurons in post-mortem PD samples.

The hippocampus is one of the most sensitive brain regions to oxidative stress [ 30], particularly the CA1 subregion of the dorsal hippocampus, which is highly vulnerable to oxidative stress due its high demand for reactive species as signaling molecules and the lower ATP production when compared to resistant neurons [ 31].

In part this is because of the inaccessibility of the relevant leptin-resistant neurons in humans and the difficulty of isolating unique neuronal subpopulations in a mass of other neurons presumably not involved in leptin action.

In this study, we showed upregulation of the GluR2 subunit in resistant OM neurons, relative to the vulnerable lumbar motor neuron population.

Understanding the mechanisms that enable any excitotoxin-resistant motor neurons to resist apoptosis and undergo compensatory plasticity is an intriguing avenue for future investigations; confirming and harnessing these potential mechanisms could present novel therapeutic targets for the treatment of ALS.

This finding is supported by an earlier study showing lower expression of GABAR subunits in vulnerable than resistant motor neurons in brainstem motor nuclei of normal rats [ 31].

Using patch clamp recording in acute spinal and brainstem slices, we show that resistant oculomotor neurons show a reduced AMPA-mediated inward calcium current, and a higher GABA-mediated chloride current, than vulnerable spinal motor neurons.

In clear contrast with physiological conditions, in the pathological brain TIMP-1 expressisn is dramatically induced in a neuronal activity-dependent manner in cortical and hippocampal neurons resistant to excitotoxicity [4].

These mechanisms involve the activation of a comprehensive transcriptional program that is triggered by enhanced synaptic activity and renders neurons resistant to harmful conditions.

However, inflammation driven expression of TIMP-1 by glia is normally preceded by the induction of TIMP-1 expression in cortical and hippocampal neurons resistant to degeneration [4], [6].