Sentence examples for resistant mutations from inspiring English sources

Sixty-seven percent virologic failures harbored viruses with ≥ 1 drug resistant mutations (DRMs); M184V/K103N was the predominant resistance pathway.

The relative fitness of viral strains with resistant mutations is a key determinant in the prevalence of transmitted drug resistance.

No secondary resistant mutations such as T790M mutation or insertions in exon 20 were found in those patients.

Despite its outstanding safety and efficacy, several resistant mutations against crizotinib have been detected in the treatment of NSCLC.

The prevalence and impact on virologic outcome of low-frequency resistant mutations among HIV-1-infected patients not previously treated with raltegravir have not been fully established.

The majority of unrecognized resistant mutations correlate with historical antiretroviral use.

Triply-resistant mutations, that is, mutations that confer resistance to three drugs simultaneously (the iskm count).

Doubly-resistant mutations, that is, mutations that confer resistance to any two drugs (the isk count).

For RIF resistance, rpoB531 was a main mutant point; 84 (60.0%) of 140 RIF-resistant mutations were associated with rpoB531.

Small hairpin RNA (shRNA) target site-resistant mutations were generated by site-directed mutagenesis (QuikChange, Agilent).

Drug-resistant mutations (DRMs) in HIV-1 protease are a major challenge to antiretroviral therapy.