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The observation that GFR, renal blood flow and urinary sodium clearance increases with terlipressin given to patients with a normal creatinine and ascites that was not diuretic resistant highlights its role as a potential therapeutic agent prior to the onset of recognised HRS.
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The structural studies clarify how S1 cleavage affects the conformation of the Notch1 NRR, and the studies of trafficking and signaling by Notch1 and Notch2 receptors engineered to be S1 resistant highlight the difficulties in generalizing conclusions based on studies of single Notch receptor family members.
Although survival rates following diagnosis have improved in recent years, patients with recurrent disease are almost invariably treatment resistant, highlighting the need for identifying new therapeutic strategies.
The growing threat from the emergence of multidrug resistant pathogens highlights a critical need to expand our currently available arsenal of broad-spectrum antibiotics.
pfcrt-associated co-expression in the CQ resistant progeny highlights CQR-specific gene relationships and possible targeted intervention strategies.
This high burden of disease together with the increasing prevalence of resistant strains highlights the need to maximize infection control measures in settings in which TB transmission is likely occurring [ 3, 4].
The isolation of E. coli O157 H7 in raw meat and the existence of antimicrobial resistant isolates highlight the potential threat to public health.
The persistent nature of HSV-1 infection, and the emergence of drug-resistant strains, highlights the importance of research to develop new antiviral agents.
Previous studies in this river network indicated that variations of microbial communities were the major factor affecting the distribution of antibiotic resistant genes highlighting the importance of understanding controls of microbial communities.
In this study, isolation of E. coli O157 H7 from raw beef, sheep meat and goat meat and the existence of resistant isolates highlight the potential threat to public health.
A previous report from the river network examined in this study indicated that variations in microbial communities was the major factor affecting the distribution of antibiotic resistant genes highlighting the importance of understanding controls of microbial communities (Zhou et al. 2017).
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CEO of Professional Science Editing for Scientists @ prosciediting.com