Lapatinib, the dual HER-2/epithelial growth factor receptor inhibitor, prolongs time to progression in patients with trastuzumab-resistant HER-2-positive breast cancer, 75, 76 and warrants evaluation in trastuzumab-resistant HER-2-positive gastric cancer.
Like her enigmatic, resistant paintings, her statements are designed to express something beyond the reach of ordinary understanding, weapons in a campaign to devalue the material and elevate the abstract.
They, and her party, may prove to be as resistant to her political aspirations as her late husband.
Her justifiably nervous older rivals were particularly resistant to her charms.
Furthermore, the overexpression of phosphoANXA2 in Herceptin resistant and Her-2 negative breast cancer tissue contributes to Herceptin-resistance [ 74].
The overexpression of miR-630 in breast cancer cells that are resistant to HER-targeted drugs significantly restores the efficacy of those drugs (e.g., lapatinib, neratinib and afatinib), which indicates that miR-630 can be used as a diagnostic and predictive marker to gauge the treatment response to HER-targeted drugs [ 91].
They have left the church that made Ms. Clementi so resistant to her son's declaration.
Nor is Sheffield (the UK's fifth largest city) the only place that seems resistant to her charms.
Mr. Emerson, the brilliant Oscar Wilde of "Gross Indecency," brings a perpetual, myopic boyishness to Tesman, and for all his infatuation with his bride, this Tesman is firmly resistant to her more extravagant demands.
In a study of children with infections caused by the new resistant staph, her group found that roughly 30percentt had family members with similar infections around the same time, suggesting that the staph was highly contagious and easily passed from one person's skin to another's.
