Exact(27)
This approach enables the exploration of a range of hypotheses to understand how cell signaling drives castration resistance, the importance of various signaling proteins in enabling castration resistant growth, the correlation between these signaling proteins, and the specific effect of various targeted kinase inhibitors in modulating the effect of these signaling proteins.
NF- κB has a significant role in anti-estrogen resistant growth of breast cancer cells and NF- κB inhibitors reverse anti-estrogen resistance, which may involve induction of NSD1.
The time to the development of resistant growth varied from 3 to 12 months.
In total, such events result in a diminished response to radiation, resistant growth and poor local control.
It is clear that the identification of alternative molecular pathways driving resistant growth would have important therapeutic implications.
This might help to explain how anti-oestrogen resistant growth of ER-positive tumours, a significant clinical problem, may arise.
Similar(33)
Near the edge of the escarpment, also in the mesophotic zone, luxurious growth of corals built discrete mounds with no evidences of wave-resistant growth fabrics.
For the sake of its children, and assuming implementation of a crash-resistant growth "paradigm," China will continue to nervously embrace the United States as parallel universe of double-edged desire.
Therapy-resistant growth may result from adaptations in the AR pathway, but androgen-independence may also be achieved by alternative survival mechanisms.
These results document that E006AA cells exhibit castrate-resistant growth, in vivo, even though they were originally established from a hormonally naïve primary prostate cancer.
E006AA cells represent a third new subtype of AR-expressing prostate cancer cells, which exhibit castrate-resistant growth characteristics even though these cells were derived from a hormonally naïve patient.
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