The characteristic histologic finding in the liver is periodic acid-Schiff- (PAS-) positive, diastase-resistant globules in hepatocytes [ 2], representing the accumulation of ATZ within the early compartments of the secretory pathway.
Astronomers could not resist giving the globules the acronym EGG's, for evaporating gaseous globules.
Importantly, the 20S proteasome can distinguish between intrinsically unstructured and other proteins, as it can digest IUPs under conditions in which native, and even molten globule states, are resistant to degradation [ 13].
The cytoplasm of the polynuclear dyskaryotic cell contained eosinophilic globules that were diastase-resistant PAS positive (PAS stain) (c).
The cytoplasm of the polynuclear dyskaryotic cell contained eosinophilic globules that were diastase-resistant PAS positive (PAS stain) (c) Fig. 5 Immunohistochemical analysis showed that the tumor was stained with vimentin (a), α1-antitrypsin (b), desmin (c), and α-smooth muscle actin (d) Fig. 6 Pathological findings of the metastatic tumor.
Interestingly, proteinase K-sensitive, molten-globule proteins are also resistant to 20S degradation.
Microscopically, the tumor was composed of pleomorphic and polynuclear dyskaryotic cells with eosinophilic globules in its cytoplasm, which were diastase-resistant Periodic acid Schiff (PAS) positive.
Microscopically, the tumors consisted of atypical cells with irregular nuclei and polynuclear dyskaryotic cells with eosinophilic globules in the cytoplasm, which were diastase-resistant PAS positive (Fig. 6a c).
In the current study, the intensity of the cellular infiltration was not affected by the genetic status, except for globule leukocyte infiltration which was higher in resistant animals after the primary infection.
Furthermore, globule-containing cells are less proliferative and more resistant to apoptosis (79).
Globule leukocyte infiltration was found higher after the challenge 1 in resistant kids.
